产品货号：
Z25327
中文名称：
ROBO1抗体
英文名称：
Anti-ROBO1 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ROBO1 Antibody |
| 指标别名 | Deleted in U twenty twenty;DUTT1;H Robo 1;ROBO1;ROBO1-Specific;Roundabout homolog 1;SAX3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | ROBO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an C-Terminal region near amino acids 1625-1650 of Human ROBO-1. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against human ROBO-1 protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest reactivity with this protein from human,mouse,rat and dog sources based on 100% homology for the immunogen sequence.Cross-reactivity will occur with all isoforms of ROBO-1.Cross-reactivity with ROBO-1 homologues from other sources has not been determined. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2.The SLIT proteins are thought to act as a molecular guidance cue in cellular migration,including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.In axon growth cones,the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex.ROBO-1 may also be required for lung development.ROBO-1 is a type I membrane protein.ROBO-1 is a widely expressed protein with the exception of the kidney.Defects in ROBO1 may be a cause of breast and lung cancer.ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.Multiple splice variants have been identified for this protein. |
| Uniprot ID | Q2M1J3 |
| 推荐稀释比 | ELISA:1:30,000 - 1:60,000 IHC:2μg/mL to 10μg/mL IF Microscopy:User Optimized IP:User Optimized WB:1:500 - 1:3,000 |
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